Ageing is a gradual, continuous process of natural change that begins in early adulthood. During early middle age, many bodily functions begin to decline gradually. The main factors which accelerate ageing are illustrated in the following figure

Telomeres are the short protective caps at the ends of our DNA strands that prevent the DNA from being damaged. These protective caps get shortened with age leading to cellular stress and DNA instability. Damaged DNA will disrupt cell communications and imbalance essential metabolic pathways, including energy-generating pathways leading to fatigue and stress.

Lack of cell communication affects stem cell regeneration due to a lack of response to nutrients, a sharp increase in the damaged cell, which is the resistance to dying, leads to increased inflammation and accelerated ageing.  

Holistic solution:

Fifth Sense has developed  Revite capsules that are scientifically formulated using a proprietary herbal blend (18 herbs) of natural medicinal herbs. The proprietary herbal blend is designed to protect telomers, prevent DNA damage, restore stem cell regeneration, reduce inflammation and balance bio-energetic pathways

Medicinal herbs are selected based on their specific functions addressing various ageing factors. These medicinal herbs are coupled with essential micro (vitamins and minerals) and macronutrients involved in mitochondrial bioenergetic functions, free radical protection, DNA protection, balancing metabolism and supporting stem cell regeneration.

Revite capsules will provide the following health benefits:

Revitalise metabolic functions, restore energy and endurance, Protect against free radicals,  Prevent DNA damage and slow down the ageing

Revite proprietary blend ingredients:

Energy metabolism and restoring mitochondria functions:  Withania somnifera, Shilajit, Asparagus Racemosus, Moringa oleifera, Tribulus terrestris, Leptadenia recticula, , Zingiber officinale,  Phyllanthus emblica, Alpha-Ketoglutarate, Glycine, Arginine, Vitamin D, Vitamin B complex, Biotin, Folic acid, Magnesium gluconate and Zinc gluconate.

Telomer-protecting herbs: Acorus calamus, Curcumin, Glycyrrhiza glabra, Convolvulus pluricaulis, Centella asiatica, Bacopa monnieri, Methionine, Biotin and Folic acid,

Stem cell-regenerating herbs: Piperine, Ocimum basilicum, L Theanine, Triphala and Astragalus membranaceus

Dosage:

Take two capsules a day

Side effects:

Revite Age capsules are not known to have any side effects.

Warning:

If you take any medication or have a medical condition, please consult your doctor before use. Keep out of children, and store at room temperature.

Disclaimer:

The FOOD and Drug Administration has not evaluated these statements. This product is not intended to diagnose, treat, cure or prevent any disease.

Selected Scientific References:

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2. Demidenko, O., Barardo, D., Budovskii, V., Finnemore, R., Palmer, F. R., Kennedy, B. K., & Budovskaya, Y. V. (2021). Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging, 13(22), 24485–24499.

3. Wu Han Toh, Chun-Bing Chen, Jude Clapper, Cheng-Chang Hsu, Hua-en Lee, Wen-Hung Chung. Evaluating the Anti-aging Effects of Chinese Herbal Medicine Rhodiola rosea L. in Cultured Keratinocytes. bioRxiv 2021.04.26.441423; doi: https://doi.org/10.1101/2021.04.26.441423

4. Vaiserman Alexander, Krasnienkov Dmytro. Telomere Length as a Marker of Biological Age: State-of-the-Art, Open Issues, and Future Perspectives . Frontiers in Genetics.11, 2021.

5. Karsono AH, Tandrasasmita OM, Berlian G, Tjandrawinata RR. Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract. J Exp Pharmacol. 2021 Aug 11;13:781-795. doi: 10.2147/JEP.S299547. PMID: 34413686; PMCID: PMC8369046.

6. Ahmed S, Ding X, Sharma A. Exploring scientific validation of Triphala Rasayana in ayurveda as a source of rejuvenation for contemporary healthcare: An update. J Ethnopharmacol. 2021 Jun 12;273:113829. doi: 10.1016/j.jep.2021.113829. Epub 2021 Jan 17. PMID: 33465446.

7. Sharma, R., & Martins, N. (2020). Telomeres, DNA Damage and Ageing: Potential Leads from Ayurvedic Rasayana (Anti-Ageing) Drugs. Journal of clinical medicine, 9(8), 2544.

8. Erastus Nembu Nembo, Jürgen Hescheler, Filomain Nguemo, Stem cells in natural product and medicinal plant drug discovery—An overview of new screening approaches, Biomedicine & Pharmacotherapy, Volume 131, 2020, 110730, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2020.110730.

9. Razgonova, M.P., Zakharenko, A.M., Golokhvast, K.S., Thanasoula, M., Sarandi, E., Nikolouzakis, K. ... Tsatsakis, A. (2020). Telomerase and telomeres in aging theory and chronographic aging theory (Review). Molecular Medicine Reports, 22, 1679-1694. https://doi.org/10.3892/mmr.2020.11274

10. Udagama, P. V. , & Udalamaththa, V. (2018). Application of Herbal Medicine as Proliferation and Differentiation Effectors of Human Stem Cells. In (Ed.), Herbal Medicine. IntechOpen. https://doi.org/10.5772/intechopen.72711

11. Guruprasad KP, Dash S, Shivakumar MB, Shetty PR, Raghu KS, Shamprasad BR, Udupi V, Acharya RV, Vidya PB, Nayak J, Mana AE, Moni R, Sankaran MT, Satyamoorthy K. Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells. J Ayurveda Integr Med. 2017 Apr-Jun;8(2):105-112. doi: 10.1016/j.jaim.2017.01.007. Epub 2017 Jun 9. PMID: 28602428; PMCID: PMC5497001.

12. Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y., & Li, D. (2016). Alpha-Ketoglutarate: Physiological Functions and Applications. Biomolecules & therapeutics, 24(1), 1–8.

13. Raguraman, V. and Subramaniam, J. (2016) Withania somnifera Root Extract Enhances Telomerase Activity in the Human HeLa Cell Line. Advances in Bioscience and Biotechnology, 7, 199-204. doi: 10.4236/abb.2016.74018.

14. Joshi, K. S., & Bhonde, R. (2014). Insights from Ayurveda for translational stem cell research. Journal of Ayurveda and integrative medicine, 5(1), 4–10. https://doi.org/10.4103/0975-9476.128846

15. Breitenbach, Michael, et al. "Mitochondria in ageing: there is metabolism beyond the ROS." FEMS yeast research 14.1 (2014): 198-212.